Most interesting in Automation

Free
App that stores/retrieves notes, providing a nonconformist solution to mental blockages & retrieval handicaps.
Detect and download updates for all of your installed software.
Free
MacUpdater keeps all apps up-to-date automatically, so you don't have to search, download, install and clean up updates manually.
Free
FileZilla (ported from Windows) is a fast and reliable FTP client and server with lots of useful features and an intuitive interface.
Manage processes and tasks on a schedule.

Top rated in Automation

ClickForMe
Free

App that automatically clicks mouse buttons for you on Mac OS X.

AutoPairs
Free

AutoPairs helps keep paired characters (e.g. parens) matched.

SecureLauncher
Free

Simple app that can be regarded as a simplified version of Parental Controls.

Auto Typer
Free

Auto Typer allows you to configure up to 5 sentences to be typed onto keyboard.

Launcher X
Free

This app is a replacement for everyone who still isn't used to the dock of Mac.

Lullaby
Free

Click on the moon in the menu bar and drag the scale to setup the timer.

Aiolos
Free

Aiolos is a small game, where you control a small ball with the mouse.

MonkeyTalk
Free

MonkeyTalk allows you to automate real, functional interactive tests for iOS.

NIWO Slumber
Free

Automate power control and activation of your computer.

WUU
Free

WUU is a program designed to keep your World of Warcraft UI addons updated.

Jitterbit Data Loader
Free

Jitterbit Data LoaderTM is a data migration tool for Mac.

VisTrails
Free

An open-source scientific workflow and provenance management system.

NNTPGrab
Free

NNTPGrab is an open source usenet download application.

Avosmac2Dock

Avosmac2Dock enables quick switching between Docks on PPC Macs running OS X 10.2 or later.

StackTop
Free

Stacktop is a Mac client for accessing most of the Stack Exchange sites.

File Transfer Command Line
Free

FTCL is a platform-independent utility for scripting file transfers.

Elsewhere: Ambient Nature
Free

Elsewhere app creates a special atmosphere around you with its ambient sounds.

Dictabulus
Free

Mac app that lets Siri dictate with no setup or user account needed.

String Replacer
Free

Find and replace a list of strings inside files and folders on your Mac directly or in batch mode.

Volumify
Free

Automatically adjust your Mac's volume according to your current location.