View and modify DNA constructs, share the files with your coworkers around the globe. Pick DNA fragments and have gene fusions automatically created, insert pieces into a plasmid without the need for restriction enzymes, simulate a cloning mechanism with an error detected and corrected.
Genetic research and biochemistry are very important today since they can help humans to fight infectious and hereditary diseases and create new and enhanced species.
SnapGene is a program that allows users to view, edit, and annotate biochemical sequences, such as proteins and DNA. It has a colorful interface that makes these tasks more user-friendly. It also makes extensive use of graphics, so the information is displayed in a clear manner.
The program has a huge amount of features that allow you to simulate the cloning of DNA sequences, the insertion of DNA fragments into a sequence, align DNA to a chromosome, and more.
Please note that the program is aimed to scientists and specialized professionals, and not to the casual or novice user. Thus, you need a solid previous knowledge to use this program and take advantage of all its features.
You can try the program before buying a license. To do so, you need to enter a valid e-mail address and click on the link you will receive. You can use the program during one full month. If you find the program useful, you can purchase a yearly or permanent license whose cost will vary, depending on whether you use it for academic or for-profit purposes, as well as on the amount of users.
v2.7 [Mar 7, 2015]
Enhancements
- You can now use Cmd+D on Mac to activate "Don't Save" when attempting to close a file with unsaved changes.
- Added MW Markers from Axygen
- Added MW Markers from Biozym
- Improved detection of lacZ-alpha.
- Improved default placement of windows.
Bug Fixes
- Fixed a crash that could occur while using the Simulate Agarose Gel dialog and switching between showing simplified and full primer duplex structures.
- Fixed a regression where the option of regenerating the enzymes used to digest the vector was not offered when designing primers for InFusion® cloning.
- Fixed a bug where unsaved annotations were not reflected in history or transferred to the product when using a fragment directly when simulating Gibson Assembly or InFusion cloning.
- Fixed a bug with showing some primer binding sites.
- Fixed a bug where designed primers sometimes did not use the desired and required Tm.
- Fixed a bug that prevented simulating Gibson Assembly using fragments(s) with 3' A or G overhangs.
- Fixed a bug that resulted in an incorrectly genereated Entry Clone when linearizing the attB insert within the BP and BP + LR cloning dilaogs.
- Fixed a bug that sometimes prevented simulating BP cloning when digesting the BP insert with an enzyme that cuts multiple times.
- Removed a partially shown color button in the side toolbar of the Primer and Edit DNA Ends dialogs.
- Fixed a bug that prevented attempting to destroy a restriction site at the numerical origin by selecting it and pressing the Delete key.
- Updated KflI to indicate it is not Dcm methylation sensitive.
- Fixed a crash that could occur after returning to interact with History view after resurrecting an ancestral sequence.
- Fixed the crasher reporter Mac OS X Yosemite.
- Fixed a potential crash in Features and Primers views when modifying annotations.
- Hide the color mode and visibility controls in the Map & Sequence Options dialog when using an embedded sequence, e.g. while using a cloning dialog.
- Fixed a bug where using a mouse wheel to scroll up or down after showing the zoom controls but not zooming could result exiting out of zoomed mode.
- Fixed a bug where it was not possible to click on feature names outside a circular map or above a linear map if shown enzymes and primers were both turned off.
- Fixed a bug where if using Gibson assembly to assemble a linear product, if the first amplified fragment wrapped around the numerical origin the product was incorrectly shifted and circular.
- Fixed a bug where if using Gibson Assembly to assemble a linear product, sticky overhangs and endpoint modifications in the first and last fragment were not properly migrate to the product.
- Fixed a bug that prevented using Gibson Assembly to assemble a linear product if either end of the product was covalently closed.
